Buffalo Bills 2025 Schedule. The 2025 buffalo bills schedule is here and we have every game, including the time and network. The buffalo bills have the hardest schedule in the nfl in 2025, according to an analyst for 33rd team.
The nfl is set to release the 2025 season schedule at 8 p.m. Buffalo opens the season with a home game against the arizona cardinals followed by a primetime thursday night game against the miami dolphins.